Cardiac

Indication

Sacubitril-valsartan is prescribed to manage patients with heart failure with preserved ejection fraction (HFpEF). Sacubitril-valsartan is also FDA-approved for pediatric patients with heart failure.

Mode of Action

• SACUBITRIL
  Sacubitril is a pro-drug that, upon activation, acts as a neprilysin inhibitor. The drug works by blocking the action of neprilysin, preventing the breakdown of natriuretic peptides, which leads to a prolonged duration of the favorable effects of these peptides.

• VALSARTAN
  Valsartan is an angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.

Benefits & Usage

The benefits of sacubitril/valsartan in HF patients are felt to be due to the increased levels of peptides that are degraded by neprilysin and the simultaneous inhibition of the effects of AT1 receptor by valsartan.